Better Work Indonesia compiled a collection of guidelines on transmission prevention and handling of Covid-19 based on guidance from the Ministry of Health, the Ministry of Manpower and other relevant Ministries of the Republik of Indonesia, the World Health Organization (WHO) and other institutions. This guideline aims to support Better Work Indonesia factories in the context of Occupational Health and Safety (K3) in order to reduce the risk of the spread of epidemics and ensure the continuity of operational activities of factories in the garment and footwear industry during the emergency situation while taking into account OSH standards. In addition, this guideline is also equipped with best practices carried out by Better Work Indonesia program member factories which can be used as a reference in the prevention and handling of the Covid-19 pandemic in the world of work.